Rapid destruction of malignant tumors by excitotoxicity and osmotic-shock medical tactics

ABSTRACT

A process, method, and devices thereof for the rapid destruction of cancer tumor(s) which are made up of thousands to millions of living malignant cancer cells. Such an approach seeks to kill said tumor(s) by causing apoptosis or excitotoxicity and/or osmotic-shock within a human or animal for medical treatment.

CROSS-REFERENCE TO PATENT APPLICATION

This application is a continuation of U.S. patent application Ser. No.14/656,142 entitled “Rapid Destruction of Malignant Tumors byExcitotoxicity and Osmotic-Shock Medical Tactics,” which was filed onMar. 12, 2015, the disclosure of which is incorporated herein byreference in its entirety. U.S. patent application Ser. No. 14/656,142claims priority under 35 U.S.C. 119(e) to U.S. Provisional PatentApplication Ser. No. 61/951,636, entitled “Rapid Destruction ofMalignant Tumors by Excitotoxicity and Osmotic-Shock Medical Tactics,”which was filed on Mar. 12, 2014, the disclosure of which isincorporated herein by reference in its entirety. This patentapplication therefore has a priority filing date of Mar. 12, 2014.

TECHNICAL FIELD

Embodiments relates generally relate to the field of bioelectronicmedicine or “electroceuticals”. Embodiments further relate to thealteration of cancer cell internal electrical signals so as to triggerand induce cell death. Embodiments additionally relate to inducingapoptosis (programmed cell death) in cancer cells due to reprogrammingthe intra-cellular operational communication network. Embodiments alsorelate to the use of calcium and related compounds and processes for usein damaging and destroying cancer cells. Embodiments further relate toexcitotoxicity and/or osmotic-shock medical tactics for use against asolid cancerous tumor.

BACKGROUND OF THE INVENTION

Solid cancerous tumors make up at least one-third of all malignancies.Such compact, fast-growing cancers are found all over the body includingthe lungs, prostate, breast, digestive tract, and skin. The presenteconomic burden to treat such a widespread disease has to be $400billion out of the $1.3 trillion cancer treatment cost leveled everyyear across the planet.

Unfortunately for the cancer patient, they are generally facing astate-of-the-art of at least a two-year miserable chemotherapy and/orionizing radiation treatment regime(s). The invention presented hereinis designed to tackle the malignance directly at the local cancer situswithout circulating toxic chemicals throughout the body, as is the casewith present-day chemotherapy regimens.

The World Health Organization (WHO) is a division of the United Nationsthat issued a press release on Feb. 5, 2014, reporting that the costglobally of cancer was estimated at $1.16 trillion in 2010. TheInternational Agency for Research on Cancer, the specialized canceragency of WHO, has reported that new cancer cases will skyrocketglobally from an estimated 14 million in 2012 to 22 million new cases ayear within the next two decades. The burden internationally has doubledover the last 20 year and it will double over the next 20.

The number of cancer deaths in the USA has risen as the population hasgrown, from 400,000 in 1990 to 550,000 in 2013.

The invention described in this document moves the main technology fortreating cancer away from chemo-therapy, which affects the entire body,to the use of tiny electrical neuro encoded signals with calcium as anaimed treatment for solid tumors both within or on the surface of thehuman or animal body.

Early Neuro-Electric History

It all started in 1780 when Luigi Galvani, an Italian anatomist,attached two dissimilar wires to the spine of a large decapitated frog.Galvani passed a current into the frog by means of astatic-electrically-charge rod and made the animal's legs jerk. Hedetermined that nerves conducted electricity and, at that moment,launched the science of neurophysiology. Galvani's friend, AlessandroVolta, the inventor of the wet-cell battery, commented in 1800 that itwas the electrical stimulation from the bi-metal wires which providedthe energy to make the frog's legs kick. Thus began the use ofstimulating currents to induce neurons to fire their signals, whichcontinues in research universities to this very day.

It never occurred to anyone in those early years that the nerves wereactually capable of generating signals on their own without therequirement for some sort of electrical stimulation. It is important torealize that there was no possible way to visualize the cells untilafter the microscope was invented by Zacharias Jansen in 1590. It wasn'tuntil later in the 1600's that Antony van Leeuwenhoek improved upon thatinvention and was able to peer at what he called “animalcules.” WhatLeeuwenhock saw were microbes, which was previously unrealized byanyone. He mentioned that there had to be some connection between whathe saw and diseases. Early microscopes were not used to study cellularor nervous system structure.

The microscope became more prevalent throughout most universitylaboratories by 1830 where many biologists began to explore the makeupof life. In Berlin around 1840, Theodor Schwann and Jacob Schleidenestablished that discrete cells were indeed the architectural buildingblocks of living tissue, be they plant or animal. This discovery pavedthe way for others to think about the individual function of manydifferent kinds of cells. Previously, in 1836, Jan Purkinje, a Czechhistology and physiologist and his student Gabriel Valentine were ableto claim: “The entire nervous system is made up of globules (cells) andcontinuous primitive fibers (axons).” In 1837, Purkinje was able todescribe brain cells with their nuclei and dendrites and the flask-likecells named “Purkinje cells,” which are efferent types.

By 1870, very few scientists knew what a neuron really was, much lesswhat it looked like, or how it worked. Therefore, it was stillimpossible to describe a three-dimensional nervous system at that timein history. But this was to change around 1877 when Camillo Golgi ofItaly was able to silver-stain individual neurons so they could bestudied under the microscope. Using Golgi's stain, a Spanish professorwas able to begin an exhaustive study of the details of neuronalanatomy. Santiago Ramon y Cajal had proposed that neurons were thesignaling units for the entire nervous system. This is often referred toas the beginning of the “neuron doctrine.” From 1879, Cajal exhaustivelystudied the brain and many of its structures as he enlarged hisunderstanding of the nervous system. Cajal published numerous technicalpapers to begin his explanation of the anatomical structure of nervesand the brain. Cajal became recognized throughout Europe by 1889 for hisimportant work. As a result, both Golgi and Cajal shared the Nobelprized in physiology and medicine in 1906.

It was not until the late 20^(th) and early 21^(st) centuries that truebioelectronic medical treatment approaches involving the use ofneuro-coded or electrical signaling technologies were possible. Recentadvances in technology have allowed for the development of bioelectronicapproaches to treating a variety of conditions, including cancer. Truebioelectronic medical treatment applications are now possible givenadvancements in electronics and a better understand of how conditionssuch as cancer actually function in the human body.

The present inventor has been involved in the development of the premierbioelectronic technology of our time as outlined in a variety ofbioelectronic medical treatment patents and patent applications coveringthe use of neuro-coded signaling technology. Validation of thisbioelectronic technology is evidence by the fact that largepharmaceutical companies and organizations are now moving into the fieldof bioelectronics, albeit many years after the present inventor'sinitial patent application filings and without much in the way ofintellectual property. For example, the monolithic internationalpharmaceutical giant GSK (GlaxoSmithKline) announced in 2013 that it waspursuing an effort toward the development of “electroceutical” orbioelectronic medicine (see “A Jumpstart-Start for Electroceuticals.Nature”, 11 Apr. 2013, Vol 496, pp. 159-161, Famm et al). Ironically,the present inventor's own research and thinking in the bioelectronicarea was captured in patent filings many years prior to GSK's 2013initiative.

To date, the primary approach to treating cancer based on bioelectronictechnology has been outlined in patents and patent applicationpublications by the present inventor. Such in inventions are disclosedin, for example, U.S. Patent Application Publication No. 2010/0286689entitled “Method and System for Processing Cancer Cell ElectricalSignals for Medical Therapy,” which published on Nov. 11, 2010; U.S.Patent Application Publication No. 2011/0270248 entitled “System andMethod to Elicit Apoptosis in Malignant Tumor Cells for MedicalTreatment,” which published on Nov. 3, 2011; U.S. Patent ApplicationPublication No. 2011/0130754 entitled “Hybrid Scientific Computer Systemfor Processing Cancer Cell Signals as Medical Therapy,” which publishedon Jun. 2, 2011; and U.S. patent application Ser. No. 12/334,212entitled “Method to Switch-Off Cancer Cell Electrical CommunicationCodes as Medical Therapy,” which was filed on Dec. 12, 2008. U.S. PatentApplication Publication Nos. 2010/0286689; 2011/0270248; 2011/0130754;and U.S. patent application Ser. No. 12/334,212 are incorporated hereinby reference in their entireties. Additionally, U.S. Provisional patentapplication Ser. No. 14/621,659 entitled “Encoded Bioelectronic Methodand System and Calcium Treatment for Slaying Cancer by Rapid Triggeringof Cellular Apoptosis and Karyorrhexis,” which was filed on Feb. 13,2015 is incorporated herein by reference in its entirety.

BRIEF SUMMARY

The following summary is provided to facilitate an understanding of someof the innovative features unique to the disclosed embodiments and isnot intended to be a full description. A full appreciation of thevarious aspects of the embodiments disclosed herein can be gained bytaking the entire specification, claims, drawings, and abstract as awhole.

It is, therefore, one aspect of the disclosed embodiments to provide foran improved cancer treatment technology.

It is another aspect of the disclosed embodiments to provide formethods, devices, and systems for the rapid destruction of malignanttumors by excitotoxicity and osmotic-shock medical tactics.

It is another aspect of the disclosed embodiments to provide for methodsand systems for the alteration of cancer cell internal electricalsignals so as to trigger and induce cell death.

It is yet another aspect of the disclosed embodiments to provide methodsand systems for inducing or eliciting apoptosis (programmed cell death)in cancer cells due to reprogramming the intra-cellular operationalcommunication network.

It is still another aspect of the disclosed embodiments to triggerkaryorrhexis in cancer cells.

It is a further aspect of the disclosed embodiments to trigger apoptosisand karyorrhexis in cancer cells.

It is also an aspect of the disclosed embodiments to provide methods andsystems for using calcium and related compounds and processes fordamaging and destroying cancer cells in association with the disclosedbioelectronic medical treatment(s).

The aforementioned aspects and other objectives and advantages can nowbe achieved as described herein. Methods and systems are disclosed forthe rapid destruction of cancer tumor(s), which are made up of thousandsto millions of living malignant cancer cells. This approach seeks tokill said tumor(s) by causing apoptosis or excitotoxicity and/orosmotic-shock within a human or animal for medical treatment.

Conventional targeted cancer therapies are drugs or other substancesthat block the growth and spread of cancer by interfering with specificmolecules involved in tumor growth and spreading or engaging inmetastatic colonization throughout the body. The disclosed embodiments,on the other hand, can implement a technology that kills the livingcancer cells directly and quickly leaving only dead cancer cells.

The disclosed embodiments can accomplish treatment during a time from,for example, 10 to 20 minutes up to multiple hours against a targetedcancer located in a human or animal. All malignant species are eligiblefor such treatment. Eukaryote classification consists of cellularorganisms whose individual cell contains a nucleus and other organellesenclosed within membranes. The dead tumors are removable from livepatients, leaving no live cancer cells.

In some embodiments, a reaction chamber can be used to enclose the tumorin a water-tight sealed non-metallic clam-shell or any other style ofenclosure that the surgical team considers appropriate. Such a reactionchamber can be sealed during the cancer killing process.

The reactive materials used within the clam-shell or other styleenclosures that destroy the malignant or benign tumor in a live patientcan include saturated calcium C++ compounds. In addition, de-ionizedand/or ionized waters, and glutamate transporters can be employed, whichcan accommodate excitotoxic reaction pathways. This includes the use ofAMPA and/or AMPAR which are quisqualate receptors for glutamatergicchemicals along with kainic acid, if needed, to trigger an overactiveglutamatergic storm. Destroying the malignant or non-malignant tumorcells may be accomplished within the clam-shell treatment chamber or byemploying any other enclosure to confine the cancer death process, whichwill also render the clean-up of the destroyed tumor more confined.

Arterial blood vessels that are feeding the tumor and venous vesselsthat are scavenging blood from the tumor should be clamped during themedical procedure to prevent contamination of other body structures bythe chemicals used in the clam-shell reaction chamber.

The treatment time for causing apoptosis, excitotoxicity, orosmotic-shock to cancer cells and/or malignant tumors is from 10 to 20minutes up to many hours, depending on the size and location of thetarget tumor.

The procedure described can be also be utilized to treat benign tumorssuch as uterine fibroid or muscle and limb tumors.

Recording its intrinsic cellular electrical pattern can also attack thecancer and then reprogram said signals so as to shut down the operatingsignal system and cause the death of the cancer.

The methods and systems of shutting down the electrical signaling systemcan be transmitted throughout from one cell to its neighboring cells ina process of relaying the death codes to electrically shut down theentire tumor.

BRIEF DESCRIPTION OF THE DRAWINGS

The accompanying figures, in which like reference numerals refer toidentical or functionally-similar elements throughout the separate viewsand which are incorporated in and form a part of the specification,further illustrate the embodiments and, together with the detaileddescription, serve to explain the principles of the present invention.

FIG. 1 illustrate a pictorial drawing of cell components;

FIG. 2 illustrates a pictorial drawing of the structure of the plasmamembrane;

FIG. 3 illustrates a junction view of the attachments between tumorcells;

FIG. 4 illustrates a pictorial drawing of the internal framework of acell;

FIGS. 5A-5C illustrate schematic diagrams depicting apoptosis, pyknosis,and karyorrhexis events;

FIG. 6 also illustrates a schematic diagram depicting karyolysis,pyknosis, and karyorrhexis leading to nuclear dissolution and ananuclear necrotic cell;

FIG. 7 illustrates example devices capable of applying C++ tumortreatment compounds, in accordance with the disclosed embodiments;

FIGS. 8-9 illustrates a layout of the neuro electric system and exampleelectrodes that can be utilized to pierce the plasma membrane tocommunicate with the tumor and its cells, in accordance with a preferredembodiment;

FIG. 10 illustrates a block diagram of a computer system that can beutilized to execute programming for executing the methods, systems,and/or processor-readable media disclosed herein; and

FIG. 11 depicts a graphical representation of a network ofdata-processing systems in which aspects of the disclosed embodimentsmay be implemented.

DETAILED DESCRIPTION

The particular values and configurations discussed in these non-limitingexamples can be varied and are cited merely to illustrate at least oneembodiment and are not intended to limit the scope thereof.

The disclosed embodiments generally cover a number of varyingembodiments including, for example, the rapid destruction of malignanttumors by excitotoxicity osmotic-shock medical tactics. Theseembodiments will be discussed later herein. Some embodiments relate tothe alteration of cancer cell internal electrical signals so as totrigger and induce cell death, which will be discussed and illustratedfirst. These embodiments can be implemented alone or in combination withthe above-referenced embodiments related to the rapid destruction ofmalignant tumors by excitotoxicity osmotic-shock medical tactics.

A primary mechanism of such embodiments relates to inducing apoptosis(programmed cell death) in cancer cells due to reprogramming theintra-cellular operational communication network. Although, it might bethought that many cancer cells are not susceptible or capable ofundertaking a programmed cell death because of the immortal nature ofhealthy cancer cells, which just keep on reproducing. However, theembodiments provide a technological approach to altering the protectivenegative charge of the cancerous glycocalyx to a positive charge tointroduce the nucleus into taking-in and accepting the apoptosis commandsignals which are aimed at shutting-down the cellular operations in anapoptosis death-spiral leading to apoptosis

Cancer plasma membrane electrical shielding protections go from negativeto positive charges and thusly open up an opportunity for the immuneT-cells, which are naturally equipped to be negatively charged, so as tobe able to attack the malignant tumor with the body's own immune system.The problem is that the cancer's glycocalyx has a negative charge whichnaturally repels the immune systems killer T-cells. A part of thesolution offered via the disclosed embodiments is the ability torearrange the negative glycocalyx to switch over to a positive charge.Hence, the killer T-cells along with other immune system features areable to attack through the glycocalyx and knock down an important cancercell defense.

Cancer tumors are made up of large numbers of cancer cells thatreproduce or multiply at incredible speed that can span 20 minutes up tosome 24 hours or longer, depending on the specific cancer species.Cancer cells continuously reproduce themselves for the life span of anygiven malignant tumor. A specific tumor continues to extend itselflocally within the body until its blood supply and space limit itsgrowth. Then it has to trigger a metastatic program whereby it releasesouter cells of the tumor to travel to other locations where it cangather blood supply and nourishment and have enough living space toexpand. All types of cells can be cancerized including neurons, bones,glandular and connective tissue, muscle, organs, and skin, nothing isexempt.

There are no prior systems that accomplish reprogramming of theintra-cellular communication system of cancer cells and specifically thenuclei of each malignant cell by means of electrically manipulating thesignals and disabling them by use of confounding electrical signalshapes. The present inventor was the first to outline such a system andapproach in other patent filings. The cancer treatment signal operatesat the approximate voltage and amperage level of the cancer cell'snucleus. Also, it is known that the cellular mechanisms and organellesoperating within the cytoplasm share electrical signal encoded languageof all the cells in a tumor. Encoded electrical signals participate inthe life, death, growth, and reproduction activities, from the plasmamembrane to the nucleus of each malignant cell living within the tumor.

The disclosed embodiments are designed to cause necrosis, apoptosis,karyolysis, pyknosis, and/or then karyorrhexis in multiple dusters ofcells simultaneously by application and distributing or transporting theconfounding treatment signals throughout the tumor. The communicationlinks include the entire cellular cytoskeleton and pathways provided bydesmosome, gap junction, and/or tight junction linkage between theadjoining tumor cells. In that manner, the signals are distributed toevery element of the tumor so they supply like-kind treatment operatinginformation throughout. However, depending on the size of the tumor atleast 1 repeat application of the reprogrammed signals may be requiredfor a complete exposure to cause programmed cell death throughout thecancer.

Part of the cancer destruction treatment is the introduction of calciuminto the nucleus to assist in triggering the nuclei of the tumor toundergo and participate in the apoptosis, pyknosis, and karyorrhexiscellular events.

Understanding Cancer Cells and a New Technology to Destroy Them

Electrical and Encoded Signal Aspects to Kill Cancer Tumor Cells

FIG. 1 illustrates a schematic drawing of cellular components of anexample cell 100. The depiction shown in FIG. 1 illustrates, forexample, cellular components such as mitochondria, ribosomes,centrosome, centrioles, the nucleus, nucleolus, and so on. FIG. 2illustrates a schematic drawing of the structure of a plasma membrane100 of the cell 100 shown in FIG. 1.

Cancer cells have a complex cellular wall called the plasma membrane, anexample of which is shown in FIG. 2, and which surrounds or spreads overall sides of the cell 100. There are some 300 types of ion pores in theplasma membrane for purposes of transporting all of the raw materialsused by the cell to live and compound the materials used by the cell toperform its duties.

The plasma membrane may have from a small number ion channels up toapproximately 200 to 400 molecular channels or more and of differentdimension through which the passage of desired nutriments andelectrolytic ions can enter the cell. In addition, the selected ionchannels can rid the individual cells of waste products in a processcalled autophagy to transport, excrete, or see to the expulsion of wasteproducts from the cellular interior into the extracellular space.

The molecular channels within the plasma membrane have molecular sizedopening for the different molecules of extracellular ions and othernutriments or materials required by the cell. An example of thematerials desired by the cell can be sodium, potassium, magnesium,calcium ions, and water.

The numbers of molecular channels are individually only able to admitselected sized ions and molecules and are present in the numbers thatapproximate the amount of ions and molecules that are required by thecell.

The passage of ions through the cellular membrane participates,generates, and/or creates a flow of electric currents within themembrane and/or on the inner surface of the plasma membrane. At pointswhere the cytoskeleton, intermediate-filaments or microfilaments isattached to the plasma membranes it allows the signals to gain entryonto the cytoskeleton so as to be able to serve as a pathway totransport the signals around the cell. The signals travel to trigger oradjust chemical reaction areas and to various organelles and the nucleusto trigger reactions and pass along cellular communication instructions,at a minimum.

The cancer cell membrane is both the site and the source of theintra-cellular electrical energy that operates the signaling processeswithin the cell. So it might be the that the cell wall plasma membraneanatomy is the actual generator of the electrical energy and helps formthe shape of the signal(s) that operates within a particular cell. Allof the malignant cells combined electrical energy that is generated inor around the plasma membrane provides for a communication system notonly within a given cell but throughout the entire tumor by means of theconductivity of the cytoskeleton as it passes from one cell to anothervia desmosomes or other special connections established between theconnected adjacent cancerous cells.

This electrical signal flow traveling throughout the many cells of thetumor allows for the generation of instructions to selected cells thatare destined to metastasize to distant sites to spread colonies for themalignancy. Such cells become soft and slightly puffy as they arereleased into the lymph or blood circulation system to travel to distantsites to start a new metastatic colony.

Other signals are generated when a tumor gets to a certain size and isunable to receive enough blood flow to nourish the rapidly growingmalignant mass so as to trigger nearby blood vessels to generate andproject additional or larger arteries directly into the tumor. Inresponse to encoded signals from the tumor, smaller arterial brancheswill bud from larger blood vessels and extend into the tumor where itwill splay into multiple arteries and enter the tumor at desiredlocations to deliver blood with its oxygen to the parts of the tumorduster that are becoming hypoxic. Without the additional blood supply,the tumors destiny will be impaired and many cells may eventually die.Otherwise, the tumor would have to limit its cell multiplication to holddown the growth size of the malignancy to accommodate the level ofavailable blood supply.

This disclosed embodiments make use of a reprogramming of the abovementioned electrical signal process to be able to alter the shape andelectrical properties of the cellular system and the system of signalsthroughout the tumor cellular duster in a given location of a human oranimal body. The most desirable signal alteration can be aimed atcausing cell death by how the treatment signals are reshaped to disturbthe metabolism, nucleolus communication, protein manufacturing andreproduction mechanisms simultaneously so as to prevent the cell fromresuming its normal duties. First, certain cell signals are recorded andthen altered by reprogramming the shape and power level of the residentcancer electrical system from the malignant cell is accomplished.Second, the treatment codes are transmitted into the malignant tumoralong with the calcium treatment.

Calcium C++ Applied to and Inserted into the Cancer Cells

C++ calcium of the finest size particles, preferably as close tomolecular size, are made up into liquid slurry for painting onto thetumor or compounded in a form so that a C++ formulation can be sprayedover the tumor with a miniature spraying apparatus with adjustable orchangeable nozzle to meet the location and size of the tumor(s).

The C++ calcium slurry or compound will smother only the cancer targetof the treatment. The contact of the C++ calcium that contacts thecalcium ion channels will be taken into the cell while the coating overthe other channels who's pore size will not accommodate the calciumparticle dimension would smother and prevent the usual other ionicparticles from entering the cell(s). Such increasing of the calcium inthe cells coupled with the denying of other ionic molecules to cellularduties will contribute to injuring the cell by osmotic-shock and movingit to its death status by apoptosis or karyorrhexis. FIG. 5A illustratesthe basic components of a cell 502 including, for example, a nucleus.Pyknosis 504 or nucleus condensing is shown in FIG. 5B. Karyorrhexis 506or nucleus fragmenting is shown in FIG. 5C. Similarly, FIG. 6illustrates a schematic diagram 600 depicting karyolysis 602, pyknosis604, and karyorrhexis 606 leading to nuclear dissolution and an anuclearnecrotic cell.

FIG. 7 illustrates example devices capable of applying C++ tumortreatment compounds, in accordance with the disclosed embodiments. Forexample, FIG. 7 indicates an example tumor 700, which is located withinthe body of a patient. Potential devices include, for example, aminiature spraying apparatus 704, such as described above. The use ofC++ calcium as part of the method to cause the death of the cancer maybe applied by many techniques, including injection, painting by brush orsprayer, wrapped cloth or gauze 702 impregnated with the calciumcompounded formulation. Also, the C++ calcium is coated the requiredamount of times around the tumor and can then be sealed with animpervious or breathable material to prevent waste products from exitingthe tumor. In addition, the wrapping treatment via such a waterproofwrap 706, for example, prevents any extracellular ions or water fromentering the tumor 700 proper. Such a treatment smothers the malignanttumor and prevents it from receiving anything but the calcium which willhave a tendency to accelerate or excite the cancer cell's internallygenerated operational electrical signals which will have the effect todrive the participating malignant cells toward apoptosis andkaryorrhexis which will lead to fragmenting the nucleus and the death ofthe cancer cells in places which have been treated, as described. Inother situations, the calcium may be injected via a syringe 708 directlyinto the tumor in association with the electrical cancer treatmentdescribed herein.

Brief Introduction to Normal Cells

All humans and animals are constructed of cells. Cells are the smallestfundamental unit of life. A cell is the smallest living structurecapable of performing all of the processes that define life. All cellshave an electrical and a chemical process. Most cells have an electricalcommunication system to operate the cell. The human body is made up ofsome 100 trillion cells representing perhaps some 300 cell-types. Eachcell-type performs a specific function such as operating muscles,glands, and vital organs. In addition, nerves, which are made ofcommunicating-cells called neurons, provide electrical regulatingsignals to operate and adjust enormous amounts of functional activitiesthroughout the body to maintain homeostasis (life equilibrium).

Normal cells reproduce by going through a cell cycle that leads toreproduction of similar cells by a process of mitosis which is where asingle cell divides and then splits into two daughter cells that areexact replications of the mother cell. Normal cells are limited as tohow many times they can reproduce by mitosis, which is probably no morethan 70 times.

Brief Introduction to Cancerized Cells:

Cancer occurs in normal cells which birth-defected distorted chromosomesand abnormal genes which lead to the formation of a defective cell whichexhibits a severe disorder of mitosis (cell division). The thrust of acancerized cell is to continuously reproduce by splitting into similardaughter cells uncontrollably, for its entire life. Some species ofcancer cells can reproduce continuously every 30 minutes while otherscould take 24 hours or longer to multiply each cell that is undergoingreproductive mitosis. When a cell becomes malignant, changes are made inits electrical communication signals.

Once a normal but defective cell becomes cancerized, it has a tendencyto grow a colony of similar cancer cells without regard to its formernormal cell duties and destiny. Defective normal cells that have thepotential to become cancerized can be potentially triggered by a numberof factors such as cigarette smoke, chemicals, viruses, radiation, orother influence. So we can say that a cancer cell emerges from a normalcell that has undergone a malignant change.

Cancer cells continue to reproduce by splitting (including the nucleus)into two daughter cells which themselves split and grow into adultcancer cells and then split again, on and on continually for the life ofthe malignancy. This process of cell splitting is called mitosis onlyproduces daughter cells, which enlarges into a massive collection ofcells, which we call a tumor. Designated cancer cells on the outer edgesof the tumor can be released and travel to other distant sites by aprocess called metastasis. Once this metastatic process proceeds, thecancer spreads to critical body parts and usually heralds a poor overalloutcome for the patient. Cancer cells are unregulated, disorganized, andengage in extremely rapid rates of mitosis. When enough cancer cells aremade, they form larger tumors, which interfere with the duties andnutrition of nearby normal cells.

Cancer does its damage in complex ways that include strangling ordistorting organs, blood vessels and nerves as well as working its wayinto bones, brain, and muscles. Groups of cancer cells are connectedtogether and feature an inter-connected electrical communication systeminternally and between each of the cells within a malignant tumor.Cancer cells perform no function that contributes to the homeostasis(life equilibrium) of the body in any way.

Cancer cells have developed ways to repel the human body immune systemby several means including erecting an electrical shield on the outersurface of the plasma membrane, which is produced by the cancer cellitself. Such a thin electrical shield is called the glycocalyx andgenerates a negative charge to oppose the animal or human immune system,which is also negatively charged. Two negative bodies repel each other,which in the case of cancer means that the immune system cannot engagethe tumor to destroy it. The body's natural immune system is noteffective in attacking cancer as it does in attacking invading bacteriaor viruses or even malfunctioning cells that have been injured, whichare usually positively charged. Positively charged microbes or ill cellsare susceptible to killer T-cell and other immune system attacks becausethe negatively charged immune defenses can approach its targetsuccessfully.

ANATOMY AND PHYSIOLOGY OF CELL COMPONENTS

The Plasma Membrane

A characteristic cell is surrounded by a thin plasma membrane, whichseparates the internal structures and operating organelles from thecells external environment. It houses and protects the contents of thecell. It consists of a bilayer of phospholipids and various proteins,which are attached or embedded.

The plasma membrane is a semi permeable structure that allows passage ofnutrients, ions, water, and other materials into the cell. It alsoallows an exit pathway for waste products and for functional two-waypassage of many kinds of molecules to adjust cell chemistry. Theprincipal purpose of the cell membrane is to provide a barrier thatcontains all of the processes and components within the living cell andto simultaneously repel unwanted substances from invading or enteringthe cell.

Since cells are electrochemical in nature, the plasma membrane is thesite for generating the cells electrical signals for metabolic and otheroperations and to serve as a means to communicate, relay and receivesignals with other cells, especially those of similar type. The nucleusand plasma membrane communicate with electrical signals. The nucleusdetermines how the cell functions and also determines the architectureof the cell and its contents. The plasma membrane uses electricalsignaling to open passageways and ion channels to allow the intake ofchemicals as well as the outflow of cellular waste products.

The thickness of a typical cellular membrane is something like 7-8nanometers. Because it is so thin, it can only endure so much of anelectrical field which does not exceed 100 mill volts, or 1 tenth of avolt. Almost certainly the electrical field would not exceed 150 millvolts to prevent a dielectric breakdown that is arcing across themembrane wall. Almost certainly exceeding 200 mill volts would producedestructive arcing.

The outside of the cell membrane is coated with a defensive glycocalyx,which is designed and produced by the cell to protect it and allow it tobe recognized. The nucleus has input into the crafting of membranedefensive characteristics. The glycocalyx can produce a negativeelectric surface charge in cancer cells so as to repel the body's immunesystem.

The cell membrane regulates the flow of materials into and out of thecell. Also, it can detect external signals and mediate interactionsbetween other cells. Membrane carbohydrates are installed on the outersurface function as cell markers to distinguish itself from other cells.

This plasma membrane contains the sites where the electrical energy iscreated and the cellular communication signals are formed. These signalsare transmitted over the cytoskeleton, which acts like wires, toregulate and trigger metabolic and functional processes within the cell.The cell nucleus communicates with all organelles and operatingstructures located within the cell. FIG. 3, for example, illustrates ajunction view 300 of the attachments between tumor cells. FIG. 4illustrates a pictorial drawing of the internal framework 400 of a cell,such as the cell 100 shown in FIG. 1.

Cytoskeleton

The cytoskeleton maintains the shape of all cells from the inside. It islike a geodesic structure that provides strength and internal areas forelectro-chemical timed reactions. Noteworthy is that the cytoskeletonextends into other cells and links up with their cytoskeleton tomaintain and form communication links into adjacent cells. Thisstructure is made up of a network of hollow-microtubules,solid-microfilaments, and solid-intermediate filaments. The cytoskeletonis anchored to the plasma membrane and serves as the “wiring” totransmit the cellular communication signals.

The cytoskeleton is made up of actin and myosin, which are also found inmuscle structures. The cytoskeleton also controls the circulation of thecytosol that is the fluid and semi-fluid that suspends the organelles.Organelles are the functioning entities of the cell that manufacture anddistribute cellular products and processes necessary for the cell tolive.

Cell Communication Connections

Individual cells operate themselves by electrical and chemical processesto maintain life and to perform the function for which a given cell hasbeen constructed. Cancer cells have different electrical signals thannormal cells.

Cells generate their electrical energy and communication signals withinthe plasma membrane. Such membrane also has electrical connections toadjacent cells of the same type to allow uniform information transfer.The nucleus is in communication with activities occurring in the plasmamembrane and, for that matter, all other activities of the cell.Electrical signaling functions control and regulate chemical activities,autophagy, regulates the mitochondrial production of ATP which serve asan energy source for the cell, and controls the ribosome's proteinmanufacturing operations. In addition, the electrical codes serve ascommunication means with the adjoining cells including when to releasecells for metastasis operations among other duties.

Cell communication is both electrical and chemical. Little scientificwork has been done to understand electrical cell signals, due largely tothe lack of electronic equipment to detect, record, and retransmit thetiny cellular waveforms operating within the cells. Over the lastcentury, studies of cell activity was confined to figuring out how thechemical activity operates because of lack of recording and sensingtechniques as well as microscopic capability to study the details ofwhat was going on.

Cytoplasm and Key Cellular Organelles

Cytoplasm and Nucleus:

The cytoplasm, a fluid that can be rather gel-like, surrounds thenucleus, which is considered an organelle. The nucleus contains the DNAgenetic information and hence, controls both the activity of the celland its structural nature. The nucleus is spherical and is surrounded bya double membrane, the nuclear membrane and envelope, which isperforated by a significant number of pores that allow the exchange ofmaterials and substances with the cell's cytoplasm and the extra moistenvironment outside which contains the ionic minerals and chemicals thatfeed the cells and provides the necessary water.

The nucleus is an electrical body which contains the cell's DNA andcarries programs to operate its electrical signals and the opening andclosing of channels in the wall of the cell's plasma membrane. Thenucleus also contains the apoptosis program for cell suicide. Dependingon the duties of the cell, some use ion channels that functionelectrically and others are influenced by chemicals that it obtains fromthe extra cellular media. Ion pumps and ion channels are electricallyequivalent to a set of batteries and resistors inserted in the membranewall, and thusly creating voltage differences between the inner andouter sides of the membrane. Such difference in the electrical valuesrange from −40 mV to −80 mV. Because the cell acts as a battery, itprovides the power to operate molecular devices that are embedded in theplasma membrane. The electrical activity sends signals that communicatewith adjoining cells of the tumor to regulate the cancer as an intragrail living body.

Mitochondrla:

An important organelle is the mitochondria, which serves as the powerstation for the cell. They are rod or oval shaped structures functioningas respiration for the cell. A number of mitochondria are scatteredwithin the cytoplasm and move in accordance with its flow. The productproduced as a biological fuel is called adenosine tri-phosphate (ATP).The manufacture of ATP results from the processing of proteins, fats,and carbohydrates. The cell communication system supplies the ATP toother organelles that require this bio-fuel to provide processing energyas needed.

Endoplasmlc Reticulum (ER):

is a network of membranes that form channels that criss-crosses thecytoplasm utilizing its tubular and vesicular structures to manufacturevarious molecules. The system is dotted with small granular structurescalled ribosomes for the synthesis of proteins. Smooth ER makes fatcompounds and deactivates certain chemicals like alcohol or detectedundesirable chemicals such as pesticides. Rough ER makes and modifiesproteins and stores them until notified by the cell communication systemto send them to organelles that require the substances. All cells inhumans, except erythrocytes (red blood cells), are equipped withendoplasmic reticulum.

Golgi Apparatus:

consist of Golgi bodies, which are located close to the nucleus andconsist of flattened membranes stacked atop one another like a stack ofplates. The Golgi apparatus sorts and modifies proteins and fats made bythe ER, after which it surrounds and packs them in a membranous vesicleso they can be moved around the cell as needed. Similarly, there is aprocess to pack up cell waste products for expulsion from the cell viaports in the plasma membrane into the extra cellular spaces.

Lysosomes:

are the digestive system for the cell. They contain copious quantitiesof acids, enzymes, and phosphates to break down microbes and otherundesirable substances that have entered the cell. They also digest andrecycle worn-out organelles to make new cellular structures or parts.

Ribosomes:

are tiny spherical organelles distributed around the cell in largenumbers to synthesize cell proteins. They also create amino acid chainsfor protein manufacture. Ribosomes are created within the nucleoli atthe level of the nucleolus and then released into the cytoplasm.

Programmed Cell Death

Programmed cell death is called apoptosis. Apoptosis is a bio-medicalterm indicating that there is a state of natural or inducedreprogramming of a cell to enter a suicide mode whereby the cell dieswithout any inflammatory process. Thereafter, the lifeless cell isphagocytized and removed by macrophages of the immune system. Apoptosiscan occur in many kinds of cells such as erythrocytes as a method to ridthe body of non-performing or defective cells. Cancer cells are thoughtto not have much opportunity to have preprogrammed cell death becausethose cells have an immortal ability to continue to reproduce andreorganize the cellular electrochemical system in a way that suits thepurpose of the cancerized cell. However, the inventor is aware thatcancer cells do get diverted to activate programmed cell death anddestroy themselves in response to an abnormal birth. It does this tocommit suicide so as to not burden the well-formed cancer cells, whichare capable of participating in the life process of a growing tumorcluster.

Cancer Cell Activity

Although, some 200 ion channels or more populate all sides of the cellplasma membrane which encompasses and shelters the interior operationsof the cancer cell. All cells, including malignant ones, must have aninternal signaling mechanism in order for them to operate the cell andremain alive as well as participating in tumor life processes ofcontinuous reproduction of more cancer cells. Any individual cell isamong the smallest units of life. Cancer cells generally have signalingability to adjacent similar cells so they can be coordinated to worktogether. Their principal duties are the bringing into the tumorsufficient oxygen and nutriments to support its principal goal ofunending reproduction by mitosis (Karyokinesis). This is a method ofnuclear division, which produces two daughter cells by a process of celldivision. This is the usual process by which nuclei are replicated inthe orderly process of mitosis as one cell becomes two. This isaccomplished by splitting the plasma membrane, cytoplasm, and organellesof the parent cell into two distinct daughter cells.

Signaling between cells of a tumor make it possible to know when torelease adult cells so that they can metastasize to other areas andbegin a new tumor colony. The metastatic cancer cells travel within theblood vessels or the lymphatic system or propel themselves across anorgan, nerve, gland, or muscle to seed a new tumor site. For theindividual cancer cells to communicate among themselves, they have toestablish links to neighboring cells. These connections between theindividual adjacent cancer cells are specifically tied to one another toallow for the sharing of signals. Ordinarily, cancer cells do notcommunicate with normal cells and are unable to operate the healthynormal cell in any way, therefore, sparing the unaffected normal cellfrom any direct operational assault.

An initiating cancer cell starts out as a normal cell, but develops achromosomal and/or a genetic chaos that drives a transformation tomalignancy. Prevailing cancer theory blames mutations in importantregulatory genes for disturbing the normal controls on cells that aredestined to become malignant. Such theory does not give credit to thedamaging changes to actual chromosomes that are seen in all cancercells. The distorted, broken, or bent chromosomes unbalance thousands ofgenes en masse and are sufficient to trigger cellular instability thatleads to serious genetic disruption and to account for thetransformation of so-called normal cells into malignant ones. The cancercells retain their electrochemical signaling and operating systems whichexisted when it was a normal cell, but now changes are ordered up for itto rearrange its cellular mechanisms in new ways to disconnect itscommunication ability from adjacent normal cells and to start rapidreproduction of more cancerous cells which are then connected tocommunicate only within its own transformed malignant species.

Interestingly the first cancer cells that are adjacent to normalunaffected cells are sometimes not wired into the rest of the tumor.Perhaps these first cells are only a demarcation line from malignant tonormal and do not have to participate in the cellular communicationsystem. Later, cells do develop the desmosome interconnectioncommunication system that allows a way for each cell to speak to itsadjacent neighbor cells. Other means of communicating between cancercells beside desmosomes are gap junctions, direct cell connections, andtight junctions. The various junctions are connected with theintermediate filaments so as to provide the pathway to transmit messagesbetween the various cancer cells.

Neither the normal cell nor the malignant cell can live without afunctioning electrical signaling mechanism to operate theelectro-chemical processes that are shelved on the cytoskeletonshelving. The cytoskeleton is the framework within the cell thatprovides a somewhat flexible geodesic-like framework to maintain cellshape, provide shelves for chemical or electrochemical process, andallow space for the organelles, nucleus, and protein manufacturingelements within the cell. The liquid within the cell is calledcytoplasm. There is a cytoplasmic streaming process that causesdirectional movement of the liquid cytoplasm as a means of localtransport for the semi-floating organelles (functional cell components).Likely, this allows these floating structures some sort of communicationbetween the cellular membrane and the nucleus as they come into closeproximity.

The cytoskeleton is composed and constructed of intermediate sizedfilaments, which actually serve as the internal structure to maintaincellular shape. But for our purposes, we know that the filamentousstructure serves to provide a highway for electrical signals to travelto sites of chemical process that reside on shelves constructed by thecytoskeleton assembly within the cell. The intermediate filaments arecomposed of compounds that are similar to the structures of muscles,which have their own electrical properties. The signals travelingthrough or on the cytoskeleton most likely initiates and stops thechemical reactions as required. The electrical signals likely skip andtravel along the surface of the filamentous network rather than withinthe central framework, again on some sort of scheduled or timed basis orin response to some event or instruction. Access to all systems withinthe cell by nucleus operations is made possible by electrical signalsresiding within the individual cells. The cells communicate with all theadjoining living cancer cells.

Cells become more electro-negative in the course of cancerization, whichno doubt is genetically mediated. Cancer cells seem to reconstruct thecellular membrane access ports to allow the importation of more sodiumand sugars than non-cancerous cells of the same size. The electricalpotential between the inner and exterior layers of the plasma membraneserve as a sort of electrical generator to supply the power to operatethe individual cancer cell

The cytoskeleton intermediate filaments are hooked together with a sortof “Velcro” at its connection points throughout the cells interior toallow some flexing of the overall cellular structure. Importantly, theintermediate filaments continue protruding through the desmosome, whichallows a connection to an adjoining cancer cell. This piercing of thecell wall within the desmosome is how signals are sent and received fromadjoining cells. There can be several desmosome connections on differentaspects of the cell wall (plasma membrane) so as to connect to cellsover, under, and beside a given cancerous cell, so as to communicatewith everybody. In the alternative, other types of cellular attachmentfor signal transduction or transmission is likely. We can never forgetthat every cell is a unit of life unto itself and has the ability toaccomplish some sort of simple primitive reasoning or organizedprocessing that is not understood at this time.

Japanese scientists have performed a great deal of work by microscopethat dates back into the 1980s on various cellular attachment schemes.Ishimaru, Kurano, and Hayashi, for example, noted that some cells in ahaematoma/sarcoma tumor island had no desmosome connection while theyfound that a great many cancer cells do utilize desmosome connections.The Japanese scientist also reported that some of the cells formedisland-like structures, the cell contact to normal cells in thestructure consisted of only simple apposition with no intermediatejunctions, desmosomes, or tight junctions, which means there is onlyminimal interrelationships. They, in a sense, became mere barriersbetween normal and cancerous cells. (Reference: Cancer Cell Biology,edited by Takeo Nagyo and Wataru Mori, published by Japan ScientificSocieties Press, Tokyo. ISBN 4-7622-0250-2 Published December 1980.)

Besides being a barrier, cells that are attached on the outer edges ofthe tumor are the non-desmosome-connected type and may become the cellsthat can be released to metastasize, although no one has suggested that.The Japanese did note that cells on the peripheral of an aggressivelygrowing cancer did not have desmosomes inter-cellular connections, butwere assembled by tight junctions or intermediate junctions mechanisms.It is not known as yet if cytoskeleton connections touch the point ofother types of cellular adhesion as a communication link to adjacentcells or make the transition connecting in mid-desmosome. There issuspicion that all the abutting cancer cells are able to communicatewith one another. It is suspected that cancer cells that are going tometastasize do prepare themselves to split-away from the tumor duster,especially when the cells are beginning to starve for blood flow andoxygen. We have a report that as the cell gets ready to metastasize, itbecomes more compressible and “squishier” according to James Gimzewskiof UCLA in a report released in December 2007. Presumably, this is apart of the metastatic process of breaking away from the mother tumor totravel elsewhere via the lymphatic, vascular system, or by directextension from the primary tumor site to a nearby region that the cancerdeems a suitably fertile area to colonize and develop a plot for a brandnew tumor. It seems that there are preferred areas that specific kindsof cancer select to establish their various metastatic colony.

It is not known how signals went through to other cells when desmosomesconnections were not in attendance. Potentially some other types of cellwall connections allow for the transfer of electrical instructions suchas releasing to go and metastasize or to take on reproduction duties.Electrical signals from the plasma membrane travel on the surface of theintermediate filaments and reach chemical processes and likely ignite orstimulate a reaction that contributes to reproduction, proteinmanufacture, or metabolic operations. Without electrical activity andthe molecular devices that operate the cell plasma membrane, the cellcould not function properly. We always have to remember that allcellular biological processes include electricity and chemicalprocesses. There are no living cells that do not comprise both achemical and an electrically based methodology to maintain functionaloperations as their purpose in life. The cell biologists are aware ofthis, but have never launched an effort to figure out how the electricalcomponent works. They are too invested in chemical actions and reactionsas that is how they began before the age of electronics made it possibleto actually trace electrical phenomenon in cells.

Cells have an electrical zone, parts of which concern the plasmamembrane, which is sometimes also referred to as the cell wall. Thecytoskeleton is anchored to the inside of the plasma membrane wall andserves as a method to generate or produce electrical instructions and aswell as seeing to distribution of the actual electrical communications.Between the inner and outer cell plasma membrane there is an electricalpotential. The cell wall seemingly can be considered a sort of battery.In fact, the plasma membrane outer and inner surfaces seem to beinvolved with the ion ports in generating electrical signals that areinvolved in operation of the cell itself. Intermediate filaments andmicrofilaments are likely carrying the signals generated within theouter and inner plasma membrane walls and the circular ion port walls.

In cancers, the charge of the outer wall takes on a protective negativecharge, especially on the very thin outermost cell coating which iscalled the glycocalyx. This glycocalyx in cancers have a continuousnegative charge protecting the malignant structure from the immunesystem, which is also electrically charged in a negative format to repelthe immune system from attacking the cancer, while non-cancerousglycocalyx coatings are positive in their protective electrical charge.All of this allows the positive protective charge to permit the negativecharged immune system to embrace magnetically the positive cellprotective elements and engage undesirable invaders like viruses orbacteria. Not so for the cancer glycocalyx with its negative shieldwhich will automatically repel the immune killer T-cells as theyapproach.

Thusly in the laws of magnetic forces, positive and negative will jointogether, while negative against negative will not make a connection,but would repel one another. This allows the cancer protectiveglycocalyx to keep the immune system forces from interfering with themalignant activity of the cancer cells.

The question comes to mind as to why have cell biologists concentratedon chemical signaling for the past 100 years, only mentioning the likelyexistence of some sort of electrical process. With microscopes, thescientists pursued every corner of the cell, including cancer cells tolearn what was going on. They also were able to name the anatomicalparts of the cell and study at least some of the chemical reactions thatoccurred on some of the cytoskeleton shelves. But, what they could notdo is determine anything about the electrical component or thecontribution of an electrical signal at a given place within the cell.When they did not have full answers, they just slid over to the nextreaction and did not answer how the complete communicational processoperates. It was easy then in those historical times to merely say itwas communicating only via chemical signals.

Gradually, university cell researchers and teaching teams continued withthe chemical reaction theory, but were usually unable to actuallyinitiate or cause any individual cellular communication reaction tooccur in a laboratory setting. Cellular biologists were able to analyzeand identify the presence of many cytokine, ions of sodium, potassium,and calcium among others. Anytime sodium and potassium are present, onecan rest assured that an electrical process is taking place. Sodium, forexample, is always involved in sparking signals, as it has no other realpurpose in cells, to the present inventor's knowledge, except to makethings move or to serve as a signal to make something happen. Alwaysrecall and remember that the cell is a little tiny unit of life, whichrequires a great deal of preparation and the use of various types ofmicroscopes to properly peer into and study. Think of 60 to 400 cellsoccupying the space taken up by a ballpoint pen dot and you can imaginehow difficult it is to study a single cell. The light microscope wasused by Robert Hooke during the 17^(th) century to study cells. Theelectron microscope first introduced by Ernst Ruska in 1933 enabledcells to be explored at up to 50,000 times magnification.

The Invention of the Electron Microscope

The tunneling microscope invented in 1981 by Binnig and Rohrer in IBM'sZurich laboratory has taken the idea of studying a single atom orsubatomic particle into the realm of possibility.

But even though one can see the anatomy and components of a single celltoday, it is still impossible to “see” the electrical process going onwithout a method to record and manipulate its neuro signal patterns forstudy. For the technical approach to be able to send a signal to triggera cancer cell to cause apoptosis (programmable cellular death) alsorequires specialized electronic equipment as is described herein as themethod for recording, storing, reprogramming, and re-transmitting thetreatment signals including versions of the imulus contact/treatmentdevice. Because of their high conductivity and strength, carbonnanotubes, for example, can serve as a suitable contact electrode of theimulus so as to pierce a cancer cell so as to communicate with the cellnucleus. The small diameter of the imulus carbon nanotube contactelectrodes provide the delicate structure to deal with the exceedinglysmall individual cancer cells. It can be appreciated, however, thatother types of devices may be used in place of carbon nanotubes.

These contact points have made all the difference in the ability forspearing and piercing the membrane and to get inside the cell for bothcollecting communication signals and to transmit re-programmed signals.The carbon nanotubes may also act as antennas in the extremely wetenvironment of the cell. The signals are extremely fast and ultra-lowvoltage at micro amps. The signal will be so small that a human wouldnot be able to detect it from a single nanotube electrode, which was inclose contact with a sensitive fingertip. It is not the power of thesignal that is important, but rather the shape and configuration of thetransmitted treatment signal that is important. There is little doubtthat we can gain control of a cancer cell electrical process, at leastto the point of wrecking cell mechanisms with what we know now.

Since the cells are interconnected with each other, it is believed thatwe will affect many cancerous cells simultaneously by insertion ofcarbon nanotubes into at least some of the cancer cells. 10,000 carbonnanotubes laying side by side would equal the diameter of a human headhair. They are sharp, as strong as steel, and have the conductivity ofcopper, the perfect electrode. The imulus receives the reprogrammedcellular communication signals and utilizes its pattern of carbonnanotubes as the entry vehicle into the cancer cell cluster or island.It is not known how many treatment applications will be needed todestroy all the cancer cells at a given site. The treatment applicationwill be brief, allowing for re-application and treatment of adjacentcells.

The certain reason for why scientists have not studied cellularelectricity is that there was no proper electronic equipment inexistence until the 1990s that could possibly detect, record, and allowtransmission of these ultra-low power very fast signals to properlystudy electrical aspects and their contribution to cellular processes.Since the cellular and biochemists were so invested in the concept ofchemical reactions being the communication methodology for cells thatthey never approached electrical activity as a partner with chemistry tooperate cell life. Electrochemical process abounds within operating andfast reproducing cells. Likely even the simplest cell that takes upspace or is part of the connective tissue, there has to be some sort ofelectrical process to maintain its metabolism and plasma membraneoperations. We doubt there is any cell that does not have an electricalprocess working away, continuously.

Neurons have an electrical signaling process and a cellular electricalprocess. Most other cells, such as cancer cells would only have aninternal electrical operating process. It is possible that cancer cellsare able to communicate to blood vessels to encourage them to extend anddirect a new vascular connection to grow into a duster of cancer cellsto supply more oxygen and nutrition needed to match the pace ofreproduction and need for nourishment.

Cellular systems are completely controlled and regulated with strictelectrical signals that are duplicated or are similar to the naturalelectrical messages that have been in existent from the earliest beingsof multicellular organisms. There are signals that require organs dotheir job and also signals that report to the nucleus of the involvedcancer cells acting as a brain of sorts to provide status report as tohow well functionality was happening. In fact, the cells that coordinateall of the organs simultaneously and confirm that body homeostasis (lifeequilibrium) was in good order.

The cell or cancer cell also has some sort of feed-back mechanism toinsure that metabolism, cell transport of food through the plasmamembrane, as well as the out-casting (excretion) of cellular waste alongwith reproduction, metastatic cell release, and propulsion of organelleswithin the cytoplasm could also be ordered up in accord with a sort ofgrand operational plan. The tumor thusly duplicates the mechanism of therelationship of all the structures and parts that make up a livinghuman. The cell is the smallest example of life and co-ordinate manyaspects of its tiny self just as a human functions by directing thesymphonies of human life.

Cell Signaling and Cancer Cell Life Operations

A cell is the smallest unit of life. Groups of cells make upmulti-cellular organisms. The human body is made up of some 100 trillioncells. Cells utilize electrical and chemical signaling in operatinginterior and exterior mechanisms depending on the composition of thecell. Some cells are operational and signal to the brain and receivesignals from the brain to regulate muscles, gland, and vital organs.Other cells only take instructions from the brain while organs andglands confine their cells to dedicated processes concerning themaintenance of life. Certain nerves and their cells are dedicated tosensing internal body status or seek information from outside the body,all with electrically encoded signals. The electrical cellular signalpattern of a malignant as well as a non-malignant cell must be able tobe detected, recorded, and it must be reprogrammable to accessoperational control of critical nucleus activity.

Cancer cells, operating as an organized tumor structure, do not conductor exchange signaling processes with normal cells. They do, however,communicate with other cells within a given tumor. They focus on theirown interior signaling and metabolism while communicating with adjacentcancer cells. Cancer cells do not participate in any operationalfunctions within a human or animal body except among themselves. Cancercells do not aid or do anything beneficial for a human body. They areselfish and only live to reproduce and steal nutriment and oxygen fromthe body in which they reside.

Cancer cells, as they form a malignant tumor, require more blood flow.To accomplish this, they have evolved a way to signal to nearby arterialblood supplies so as to order-up the formation of buds on the arterythat ultimately extend into blood vessels that travel over to andpipeline into the tumor. With additional blood flow, the tumor continuesto reproduce and extend its dominance over its primary site.

Examples of some processes that cells naturally perform via signals:

-   -   a. Cell reproduction    -   b. Encoding of proteins    -   c. Regulation of growth    -   d. Differentiation of the cell    -   e. Internal cell communication    -   f. External signaling to other cells    -   g. Excretion of chemicals    -   h. On or off control of secretions or excretions    -   i. Timing of operations for cellular organelles    -   j. Various levels of signaling within the nucleus    -   k. Signals between plasma membrane and nucleus    -   l. Operation of transport mechanisms in cell wall

Cell signaling is accomplished by a combination of electrical andchemical interactions. Different types of cells require a varied levelof signaling qualities. The creation or generation of a given cellsignal begins in the plasma membrane where raw material and chemicalions are taken in from the extracellular matrix to both generateelectricity and establish the signal format. The plasma membrane is asort-of cell wall and the area that takes in the required raw materialvia its ion channels. Ion channels open and close to allow passage intoand from the cell interior. Electrical signals are likely generated inthe plasma membrane before they are sent via the cytoskeleton, all aboutthe cell to go and participate and contribute to cell operations.

The cytoskeleton also serves as a geodesic-style dome providing aframework to shape and support the cell. In addition, the cytoskeletonserves as the pathway by which cell signals generated in their plasmamembrane travel within and around the cell to do its work. In addition,communication to adjacent cancer cells could happen through connectionssuch as desmosomes, which are extensions, that bridge and allowcommunication between adjacent cells of a tumor. These connections actalso as a pathway for the neuro-signaling cancer treatment technology todestroy the tumor.

The small size of individual cancer cells requires a variety ofmicroscopic electrodes to record the basic communication signals, whichare initially generated in the plasma membrane and within eachindividual cellular nucleus electrical system. Transmitted treatmentsignals are spread throughout many cancer cells simultaneously. Thisrepresents the dawn of an entirely new treatment approach using onlytiny encoded signals to destroy cancer quickly.

Normal and Cancerized Cells Operate Via Encoded Electrical Systems

The human body is made up of some 100 trillion cells. Cell theory simplystates the cell is the fundamental organizational unit of life. Indeed,the cells of the human or animal body represents the smallest example ofactual life. All cells have electrical and chemical capability. Cellstake in raw material and create energy, make protein, and expel waste aswell as perform some function for the body in which it lives. A richneuro-electric encoded communication system abounds in the cells of allliving bodies as a means of controlling and regulating all of the lifeprocesses and for maintaining homeostasis (life equilibrium).

Cancer cells for the most part begin life as normal cells. Although,cancerized cells can begin life already in the malignant state. However,in the process of cancerization remarkable alterations in thecharacteristics occur, including changes in the cell electricalcommunication signals. In a certain way we can say that a cancer cellstarts life as an ordinary cell within which resides the mysteriousseeds of defective genetics, which can be tricked into malignancy. Thischange causes the cell to turn into a malignant cell, which includesalterations to its operational destiny.

During this metaplasia into cancer, the cells modify their internalsignaling process to meet their new destiny to rapidly reproduce moremalignant cells. Whatever duty the cells had prior to their turningmalignant is no longer of importance. Cancerized cells can reproducethemselves at speeds from 20 minutes to 20 hours, depending on thespecies.

Tumors can consist of millions or even billions of cells. So, if amillion cells reproduce in 5 hours, that would result in some 2 millioncells and so on as time passes. Cancers drain the oxygen and nutrientsfrom nearby blood vessels with which to grow ever-larger tumors in thebody as they go metastatic to various predictable places within thebody. While cancerized cells can reproduce forever, normal healthy cellscan seldom reproduce more than a total of 70 replications in their lifespan.

The only stimulus for tumor growth is the available blood and nutritionsupply that they take in locally and those very tiny encoded signalsthat organize and control the operation of the tumor and its cellularmembers. Schuler and her team of scientists also established that therewere only analog signals operating within animal and human bodies. Theresimply was no cells, cancer or healthy, operating in a digital modewithin any living mammalian being.

Man-made electronics generally function in a digital mode. Specialanalog computers and medical treatment devices can be expected to appearin the marketplace

Injury of Cells, Neurons and their Axons

Injuring nerves and their cells as a result of stopping blood flowand/or the generation of neuro-electric signals will cause loss offunction. Morphological evidence of cell death usually is not apparentfor about 6 hours. Operationally, a neuron including its axon respondsto the loss of flow of their neuro-electric signals for 8 to 15 minutesbefore further decay depending on how serious the injury is.

All living cells depend on their blood supply and their electricalprocess to maintain their life activity. With any extended switch-offtime of the encoded signals involved with internal life processes of acancer cell and its nucleus can play an important part in destroying orinjuring an entire active malignant tumor.

Application of Neuro-Electric Signals to Destroy Cancer Cells

With the design and construction of a special hybrid scientific computersystem, including the custom software, cancer cells are ready to beaccessed and reprogrammed to destroy themselves. The cancer cells willbe first recorded as to their internal communication signals and thensuch codes shall be modified to confound the cancer's cells metabolicand signaling processes. The anticipated results are that the nucleusshall detect the treatment signals and trigger apoptosis (programmedcell death). It is expected that a cascade of Igniculus or Interclusiosignals will be conducted via the cytoskeleton and desmosomes or otherinterconnections within a tumor to transmit the “death codes” throughoutadjacent cancer cells, all of this designated to destroy the entiretumor.

It may be necessary that tumors can be killed in sections as it is notknown yet how far the interclusio signals will penetrate during a singletreatment. Depending on the mass of a living tumor, the extent andduration of application of the treatment signals will be estimated andplanned. Effective treatments are expected to take about 10 minutes andwill utilize only reprogrammed cancer death-codes to cause apoptosis(programmed cell death). No conventional radiation or chemotherapy isexpected to be necessary. The treatment process is accomplished bytransmitting the formatted electrical signal pattern through the plasmamembrane wall into the cell interior. Ultimately, the electrical signalis directed into the nucleus interior itself to accomplish certaincancer cell death by karyorrhexis.

No medical scientist and inventor has as much practical knowledge andexperience or creative intellectual property regarding cellular andnerve encoded systems as Eleanor Schuler. Schuler estimates thatreprogramming and alteration of the internal electrical encoded cellsignals will rapidly alarm the nucleus and release or trigger it'ssuicide apoptosis commands in a matter of minutes, once the reprogrammedcancer cell signals and calcium applications have been placed in thecorrect locations. Such signals are anticipated to travel into the tumorand transmit signals that collapse its cellular communication systemwith death-codes.

This technology is expected to become the definitive treatment for solidcancerous tumors in mammals.

The pending patents stand alone as the pioneering intellectual propertyin this very special field of neuro-signal encoded medicine. It isexpected that the destruction of cancer by apoptosis will spawn a verylarge global neuro-electric medical industry. Such technology forcausing cancer cells to commit suicide is expected to largely displacethe chemotherapy industry that dominates present day cancer diseasetreatment.

Cancer Diseases are Found Across the World and Resist StandardTreatments

Of the maladies and ailments of mankind, nothing is more disappointingand terrifying than cancer. Treating malignant tumors has reached theproportions of a major $ Trillion world industry. Despite many levels ofresearch and testing efforts using chemotherapy, ionizing radiation andsurgical approaches against active cancer diseases continue to bedisappointing as to any reliable, effective, or rapid cures.

Some Avenues for Destruction of Cancer Cells

Necrosis, apoptosis, autophagy, stasis, macroautophagy, cell starvation,tumor reduction, shut-down of mitochondria production of ATP, consumingcontents of cytoplasm, incipient starvation, blebbing, cell shrinkage,nuclear fragmentation, chromatin condensation, chromosomal DNAfragmentation, pyknosis, karyolysis, karyorrhexis. Human bodies havecomplex daily cellular maintenance duties to dispose of some 50 millionworn out cells every day. Average adult humans operate an ever-busyapoptosis and repair system. Key elements are briefed below.

Necrosis

Necrosis is a form of traumatic cell death that results from acutecellular injury. Necrosis death of cells can happen because of infectionor fever that result in the premature death of cells in living tissue.Untreated necrosis results in a buildup of dead and decomposing celldebris in the region of actual cell death (e.g., a classic example isgangrene). Cells dying from necrosis don't follow the usual apoptosistransduction pathways.

Apoptosis

Apoptosis is the original programmed cell death technology that helpsrepair and model the body beginning with birth and continuing onthroughout life. Some 50 billion cells die every day due to apoptosis.For example, the lining of the digestive tract from the stomach liningon to the colon undergoes apoptosis every 3 to 5 days to replace theentire inner lining of the digestive tubular structures. Red blood cellsare programmed to replace themselves every 90 days by undergoing killingby the spleen and the bone marrow manufacturing new blood cells andreleasing them back into the blood vessels to do their work of carryingoxygen and carbon dioxide.

There are interesting and important methods to destroy cancer cells thatproduce one or more apoptosis events or tactics to gain control of thecellular electrical system. Regarding the key target of a livingmalignant cell is the nucleus.

The nucleus is the literal brain of operations for the cell. In a tumor,a million cells or more are slaved together to operate the cancer as ifit was a kind-of special organ who's duty is to continue reproducingmore malignant cells on into the future with no end in sight. Thelimiting element is the availability of enough blood and its associatednutrition to operate the signaling system.

Apoptosis is the principal process of programmed cell death. Technicalevents that appear during an apoptosis event include characteristicchanges that include cell shrinkage, generating heat, hypoxic events,and an increase in calcium concentration, which causes snappy signalingin the nucleus that triggers and orchestrates the imminent apoptoticevent.

Autophagy

Autophagy is from the Greek definition as “self-eating.” Inside a livingcell's cytoplasm are organelles identified as autophagosomes that movearound the cell to sweep up viruses, bacteria and worn out materialsfrom the cell itself. The autophagosomes bag up or concentrates the cellsludge and worn out protein and other debris to be handled by recyclingorganelles that float in the cytoplasm. Some of the unusable waste isforced out of designated cell ion ports by pumping it through the plasmamembrane into the extra-cellular fluid surrounding the cells. Since someneurons live as long as the body they have to use autophagy to maintainthe quality of the overall cell health. Autophagy and mitochondrion canwork together to cause apoptosis to trigger programmed cell death to ridthe cell of unwanted cell component that can't be rehabilitated. Unlikenecrosis, apoptosis produces cell fragments called apoptotic bodies thatphagocytic cells are able to engulf, eat, digest, and then dispose of inleague with the autophagy process in a well-established method to keepthe overall cellular system in order.

Pyknosis

The irreversible concentration of chromatin in the nucleus of a cellinvolved in necrosis or apoptosis. This is followed by condensing itsnucleus before expelling it to become a reticulocyte. The maturingneutrophil will be involved in forming blebs that stay in the cell untilthe end of its life. Blebs are distortion of the nucleus and the cancercell shape. It is the formation of protrusion or pimple structures ofwhat was previously symmetrical nucleus and overall cell shape. It isfollowed by fragmentation of the changing nucleus on its way toexperiencing karyorrhexis. During bleb formation of the nucleus, a sortof pimple formation gives the nucleus an unhealthy appearance, whichdoes not improve.

Karyorrhexis

Karyorrhexis is the ultimate bursting of the cellular nucleus intomultiple pieces that cannot be repaired. The nucleus of a cellrepresents and is equivalent to the brain of any creature; once it isbroken into pieces it is finished.

Karyorrhexis is an important cancer killing skill which is accomplishedby fragmentation of the cancer cell nucleus into apoptotic bodies whichare then engulfed and ingested by phagocyte(s). A phagocyte is a specialcell that locates and surrounds broken cellular components and then eatsthem. There are fixed phagocytes that live in the liver, bone marrow,and spleen. Such phagocytes are represented by neutrophils andmacrophages. Also, there are freely moving phagocytes such as leukocytes(white blood cells) that circulate in the blood stream to do theirclean-up work. The job of the nucleus is to control all cellularoperations and to participate in communication and coordination withnearby cells. If a nucleus is fragmented, it is like fragmenting thebrain of a human or animal, life cannot go on with such as injury

High Speed, Hybrid Scientific Signal Processor to Destroy Cancer TumorCell Nuclei

A high-speed analog cancer cell unit can be utilized to record cancercell operational electrical signals and to reprogram such signals beforetransmitting them back into the malignant cells to trigger apoptosis andkaryorrhexis. Such a unit or system is discussed in more detail withrespect to the FIG. 8, which illustrates a computer system 812 having atleast a processor 820 and a memory 822. A cancer cell cluster or tumoris illustrated at 810 in FIG. 8. By means of an imulus or other probe,such as those shown in FIG. 9, the resident electrical signal or signalsof the cancer are then provided to the computer system 812 for storingvia memory 822 and processing via processor 820. Typically, the computersystem 812 is digital, and in order to accept the electrical signalsfrom the tumor 810, an analog to digital converter 814 can be used. Ifthe computer system 812 employed includes an embedded analog to digitalconverter, the converter 814 can be omitted.

It is the computer system 812 in which all of the processing, analysis,and generation of confounding electrical signals occurs. In order totreat the tumor 810, the confounding electrical signals are applieddirectly to the tumor 810 via an imulus or probe after conversion toanalog state by a digital to analog converter 816.

The technical approach is to initially develop a number of cancer cellresident electrical signals for different species of cancer and perfectreprogrammed confounding type signals. The user then sorts andreprograms the natural signals of the cancer cell and tinkers with theelectrical signatures and coding to finally select appropriate treatmentelectrical signals, also known as confounding electrical signals. Thisis followed by devising a library/database of treatment signals. Thecollection of treatment signals may be cataloged as to the species ofcancer and anatomical location. During treatment of a cancer, the firststep is to identify the species of cancer and then select the properconfounding signal with which treatment will begin. Once the treatmentteam knows the species such as carcinoma or sarcoma, they select fromthe computerized library/database the most appropriate treatment signal.There are approximately about a total of 200 cancer species inexistence. Ultimately the treatment library will be composed of at leastas many definitive cancer confounding, interclusio, or mortifiersignals. Carcinoma species is the most common cancer and likelyrepresents something like 50% of all cancerous tumors arising throughoutthe body.

Once the cancer cell locations in a patient have been identified, thecancer cellular electrical activity has been recorded and analyzed, andan appropriate response has been determined, the medical staff candevelop and initiate a treatment protocol. The protocol will followestablished medical procedures with the main objective of applying theproper signals and appropriate electrical energy to the cancerous cellsto cause apoptosis. The computer system 812 contains a low voltage andamperage power supply to ensure the correct voltage and amperage isdelivered to the cancerous cells. The electrical energy delivered isless than 1 volt and less than 10 millionths of an amp for a pulsedapplication on the cancer over a few seconds. The treatment may berepeated. The range of electrical treatment may span upwards of 2 voltsand 70 micro amps and as low as one-tenth of a volt or possibly evenlower at 2 micro amps or even lower into the picoamp range.

The treatment time may extend, for example, up to 4 minutes or more andmay be repeatable over days if required. The treatment signals in theform of an electrical signal will have a definable shape and be encodedto confound the natural electrical activity found in the cancer cellplasma membrane wall and within the very interior of the cell proper.With the use of the proper code to shut off cellular electricity, theresult is apoptosis of the cancer. Cancer death can begin in less thanan hour once its metabolic processes are shutdown. Cell death actuallymay occur in less than 10 minutes as a human brain cells do when bloodcirculation or electrical signals are turned off. Natural resuscitationof the cancer cell may be possible if the confounding electrical signaltreatment is too brief or incomplete. Otherwise, irreversible biologicaldecay will set in as long as the cellular process has been severelydamaged by the treatment signals. The body immune system is expected toconsume the dead or dying cancer as soon as the outer cell membranenegative electric charge is off or markedly diminished. It is the strongnegative outer electrical charge of the cancer cell membrane glycocalyxthat keeps the immune cells from attacking since they too are negativelycharged and would be repelled from one another. Normal cells have outercoat charges that are usually positive and are therefore accessible tothe negatively charged immune system cells.

Treatment can be accomplished, for example, with a small cable of totaldiameter no more than a wooden match stick. The imulus or treatmentcontact unit 918, as shown schematically in FIG. 9, can be implementedin the context of a small device, which in some embodiments may containup to hundreds or thousands of carbon nanotubes 920. Such nanotubes maybe hollow or partitioned. In addition, they may be coated with a metaldeposition or chemical that interferes with the glycocalyx strongnegative electrical charge. The carbon nanotubes equipped imulus 918will appear under a microscope like a hairbrush. Each nano fiber tube isabout one-ten-thousandths of a human hair in diameter. The imulus 918can be used to both record and apply the treatment signal and may be ofdifferent sizes to fit the various cancer dusters. The physical approachto the cancer can be guided by fluoroscopy or other visualizationapparatus or system to insure that the treatment is applied properly andcompletely and is directed at the correct target.

The imulus 918 can be positioned to make contact with the tumor as theprimary junction between the computer system 812 and the malignantcellular tumor 810 which is to be treated. Some modified nano carbontubes may also act like an antenna and only need to be in closeproximity of the malignancy to send in the interclusio or impulsesmortifier codes. Insertable links, implantable antennas, and contactpads or implacable treatment needles of carbon or metal can be in thearsenal of imulus attachments, among others. An alternative imulus 922is also shown in FIG. 9 with a shape capable of piercing a cancer celland/or cancer tumor or duster of cancer cells.

It is preferred that analog computers are used that are as sensitive andable to record the cancer electrical signals as required. As analogcomputer developments advance they may be more suitable and be thesystem of choice in destroying cancer cell life. Otherwise the system asillustrated can utilize A-D and D-A converters 814, 816 interfaced witha digital processor in the computer system 812 using appropriatesoftware to control confounding signals.

The main treatment quest can include locating all of the cancer islandsand dusters for treatment. Signals to shut down the cancer must affectevery malignant cell at a given site. Communication can travel throughportions or layers of tumor cells, traveling from cell to cell.Therefore, moving the imulus around the tumor 810 may be necessary insome situations to make certain that every cellular communication systempresent within the malignancy is disabled or destroyed.

While the preferred signal handling system embodiment to destroy cancercells is a full analog technology, the current state of computer systemsmay not be able to deliver such a scientific computer that would work atthe extremely ultra-low voltages and at the speed required to captureand record the natural signals of cancers. Therefore, FIG. 8 outlinesthe requirements for a hybrid system to process cancer treatment codes.The system of the invention can utilize, for example, a hybridanalog/digital computerized system which requires at its entry an A-Dconverter 814 of high sensitivity to record the exclusively analogcellular signals of cancers. Secondly, the signal has to be transferredinto a digital processor in the computer system 812 where it can bestored and reprogrammed to confound the natural cellular signals andcontrol any power supply required.

The computer system 812 includes several components. First, it shouldhave a typical laptop or desktop computer for control, data acquisition,programming, and application of treatment. In some embodiments, however,the computer system 812 may be a mobile device such as, for example, atablet computing device or a smartphone or such similar hand helddevice. The computer system should in some situations allow for storageof ambient and environmental signals as well as potentially interferingbiological noise so that the treatment or confounding electrical signalscan be as pure as possible.

FIG. 10 illustrates a block diagram of the computer system 812, whichcan be utilized to execute programming for executing the methods,systems, and/or processor-readable media disclosed herein. Computersystem 812 as shown in FIG. 10 can be implemented as a general computingdevice in the form of a computer 110, which may include a processingunit 820, memory 822, removable storage 112, and non-removable storage114. Memory 822 may include, for example, volatile memory 106 andnon-volatile memory 108. Computer 812 may include or have access to acomputing environment that includes a variety of computer-readablemedia, such as volatile memory 106 and non-volatile memory 108,removable storage 112 and non-removable storage 114. Computer storageincludes, for example, random access memory (RAM), read only memory(ROM), erasable programmable read-only memory (EPROM) and electricallyerasable programmable read-only memory (EEPROM), flash memory or othermemory technologies, compact disc read-only memory (CD ROM), DigitalVersatile Disks (DVD) or other optical disk storage, magnetic cassettes,magnetic tape, magnetic disk storage, or other magnetic storage devices,or any other medium capable of storing computer-readable instructions,as well as data, including video frames.

Computer 812 may include or have access to a computing environment thatincludes input 116, output 118, and a communication connection 120. Thecomputer may operate in a networked environment using a communicationconnection to connect to one or more remote computers. The remotecomputer may include a personal computer (PC), server, router, networkPC, a peer device or other common network node, or the like. Thecommunication connection may include a Local Area Network (LAN), a WideArea Network (WAN), or other networks. This functionality is describedin more detail in FIG. 23.

Output 118 is most commonly provided as a computer monitor, but mayinclude any computer output device. Output 118 allows a user to navigatethrough the virtual environment embodied by computer system 812. Inaddition, input 116, which commonly includes a computer keyboard and/orpointing device such as a computer mouse, allows a user to select andinstruct computer system 812. A user interface can be provided usingoutput 118 and input 116.

Processor-readable or computer-readable instructions, for example,program module 125 are stored on a computer-readable medium and areexecutable by the processing unit 820 of computer 812. Program module125 may include an application. A hard drive, CD-ROM, RAM, Flash Memory,and a USB drive are just some examples of articles including acomputer-readable medium.

FIG. 11 depicts a graphical representation of a network ofdata-processing systems 950 in which aspects of the disclosedembodiments may be implemented. Network data-processing system 950 is anetwork of computers in which embodiments may be implemented. Note thatthe system 950 can be implemented in the context of a software modulesuch as program module 125. The system 950 includes a network 202 incommunication with one or more clients 210, 212, and 214 one of whichmay be, for example, computer system 812 of FIG. 8. Network 202 is amedium that can be used to provide communications links between variousdevices and computers connected together within a networked dataprocessing such as computer system 812. Network 202 may includeconnections, such as wired communication links, wireless communicationlinks, or fiber optic cables. That is, network 202 may be in someembodiments a wireless communications network (e.g., cellular, Wi-Fi,etc.), and one or more clients such as 210, 212, 214, etc., may be ahand held mobile communications device such as, for example, asmartphone, tablet computing device, etc. Network 202 can furthercommunicate with one or more servers 204 and 206 and a memory storageunit, such as, for example, memory or database 208.

In the depicted example, server 204 and server 206 connect to network202 along with storage unit 208. In addition, clients 210, 212, and 214connect to network 202. These clients 210, 212, and 214 may be, forexample, personal computers or network computers. Computer system 812depicted in FIG. 8 can be, for example, a client such as client 210,212, and/or 214. Alternatively, computer system 812 can be implementedas a server, such as servers 204 and/or 206, depending upon designconsiderations.

In the depicted example, server 204 provides data, such as boot files,operating system images, applications, and application updates toclients 210, 212, and 214. Clients 210, 212, and 214 are clients toserver 204 in this example. Network data-processing system 950 mayinclude additional servers, clients, and other devices not shown.Specifically, clients may connect to any member of a network of servers,which provide equivalent content.

In the depicted example, network data-processing system 950 is theInternet with network 202 representing a worldwide collection ofnetworks and gateways that use the Transmission ControlProtocol/Internet Protocol (TCP/IP) suite of protocols to communicatewith one another. At the heart of the Internet is a backbone ofhigh-speed data communication lines between major nodes or hostcomputers consisting of thousands of commercial, government,educational, and other computer systems that route data and messages. Ofcourse, network data-processing system 950 also may be implemented as anumber of different types of networks such as, for example, an intranet,a local area network (LAN), or a wide area network (WAN). FIG. 11 isintended as an example and not as an architectural limitation fordifferent embodiments disclosed herein.

The aforementioned description has thus been presented with respect topreferred and alternative embodiments of the present invention, whichcan be embodied in the context of a data-processing system such ascomputer system 812 in conjunction with program 125, data-processingsystem 950, and network 202 depicted in FIGS. 10 and 11. The disclosedembodiments, however, are not limited to any particular application orany particular environment. Instead, those skilled in the art will findthat the systems, methods, and processor-readable media described hereinmay be advantageously applied to a variety of system and applicationsoftware, including database management systems, word processors, andthe like. Moreover, the systems, methods, and processor-readable mediadisclosed herein may be embodied on a variety of different platforms,including Macintosh, UNIX, LINUX, and the like. Therefore, thedescriptions of the exemplary embodiments, which follow, are forpurposes of illustration and not considered a limitation of thedisclosed embodiments.

It will be understood that the circuits and other means supported byeach block and combinations of blocks can be implemented by specialpurpose hardware, software, or firmware operating on special orgeneral-purpose data processors, or combinations thereof. It should alsobe noted that, in some alternative implementations, the operations notedin the blocks may occur out of the order noted in the figures. Forexample, two blocks shown in succession may, in fact, be executedsubstantially concurrently, or the blocks may sometimes be executed inthe reverse order.

The disclosed embodiments thus cover a rapid method to destroy livingcancer cells and the tumors they create including metastatic off-springof such tumor(s), regardless of their location within the human oranimal body.

Computer generated analog treatment signal(s) which are aimed at thecellular nucleus are transmitted through the plasma membrane or its ionchannel pathways. Signals would travel directly through the phospholipidbilayer and through the internal membrane surface so as to enter thecellular interior. The treatment signals may travel on the intermediateand/or microfilaments located in the cancer cellular interior to reachthe nucleus.

The treatment signal(s) may reach and influence the nucleus as intended.Such signal(s) are expected to participate in causing apoptosis andkaryorrhexis which leads to the fragmentation and destruction of suchnucleus as an operating organelle of the cell. A fractured nucleus wouldlead to rapid death of the cell which will be unable to reproduce orcommunicate with its neighboring cells within the tumor proper.

As part of the cancer destruction process, calcium can be injected intothe process with the nucleus and also to influence the energy source ofthe cell. That source is an organelle that floats around in thecytoplasm called a mitochondrion.

The calcium influences the operational pace of mitochondrion output byconverting adenosine diphosphate (ADP) in a resynthesizing process asadenosine tri-phosphate (ATP). ATP is a kind of bio-fuel for the cell inoperation as a cellular fuel to free up chemical energy which istransferred from ATP to provide the chemical source required foranabolic reactions for cellular processes as it reverts itself back toADP.

Based on the foregoing, it can be appreciated that a number ofembodiments are disclosed herein, preferred and alternative. Forexample, in one embodiment, a method for destroying cancer cells can beimplemented and can include, for example, the steps or logicaloperations of inserting calcium ions into a nucleus of at least onecancer cell among a plurality of cancer cells; and fragmenting thenucleus in many cancer cells among the plurality of cancer cellssimultaneously with the transmission of destructive analog electricallyencoded signals to provide a medical cancer treatment thereof. Inanother embodiment, a first target of medical cancer treatment is aimedprincipally into the nucleus and mitochondrion bodies of a malignancyassociated with the at least one cancer cell.

In another embodiment, a step or logical operation can be implementedfor simultaneously treating thousands or millions of nuclei andmitochondrion cells among the plurality of cancer cells with calcium andneuro encoded analog signals to cause rapid killing of a tumorassociated with the malignancy and/or the plurality of cancer cells. Inyet another embodiment, an encoded electrical signal burst can beutilized on each malignant solid tumor associated with the at least onecancer cell, regardless of it being within the body or on the surface ofa patient thereof, as a part of the medical cancer treatment.

In still another embodiment, a step or logical operation can beimplemented for injecting the calcium into, painting the calcium on,pasting the calcium on, and/or spraying the calcium onto a surface ofthe plurality of cancer cells operating within a tumor, so that thecalcium boosts cellular resident operating signals associated with theplurality of cancer cells above their natural electrical excitabilityand/or metabolic pace throughout. In still another embodiment,emplacement of calcium C++ on both inside a tumor associated with the atleast one cancer cell and on an outer plasma membrane of the at leastone cancer cell can be conducted simultaneously. In yet anotherembodiment, a step or logical operation can be provided forover-wrapping a tumor associated with the at least one cancer cell amongthe plurality of cancer cells with a waterproof material if the tumor issituated in a location accessible to the over-wrapping. In still anotherembodiment, a step or logical operation can be provided for maintainingthe waterproof material on the tumor for a particular period of time orsuch time as a physician deems appropriate.

In yet another embodiment, a step or logical operation can be providedfor smothering a tumor associated with the at least one cancer cell froma calcium saturated wrap to deny access to extra cellular soluteconcentration around the at least one cancer cell or the tumorassociated with the at least one cancer cell to inhibit a transport ofsolutes and ions and water to cause the at least one cancer cell tosuffer osmotic shock causing swelling and either to burst or undergoapoptosis. In still another embodiment, a high-speed hybrid system suchas system 800 shown in FIG. 8 can be employed to record from varyingtypes of electrodes, signals associated with the at least one cancercell to process the signals to produce the destructive analogelectrically encoded signals. In another embodiment, one or moreelectrodes among the varying types of electrodes can be capable ofpiercing a plasma membrane associated with the at least one cancer cell.In yet another embodiment, at least one electrode among the varyingtypes of electrodes can be provided as, for example, a pipette electrodeor a patch-clamp hollow glass electrode with saline solution electrodesso as to enter calcium, potassium, or sodium ion ports of the at leastone cancer cell to record the signals associated with the at least onecancer cell.

In another embodiment, a system for destroying cancer cells can beimplemented. Such a system can include, for example, a processor and/ora memory; a device for inserting calcium ions into a nucleus of at leastone cancer cell among a plurality of cancer cells; and wherein thenucleus is fragmented in many cancer cells among the plurality of cancercells simultaneously with the transmission of destructive analogelectrically encoded signals processed by the processor and/or retrievedfrom the memory to provide a medical cancer treatment thereof.

We now turn our attention to the rapid destruction of malignant tumorsby excitotoxicity and osmotic-shock medical tactics.

Excitotoxicity Tactics Against a Solid Cancerous Tumor

The first step of this targeted cancer medical treatment presented caninclude an excitotoxicity tactic of wrapping the tumor with watersaturated cloth covering(s). The second step is to seal the tumorcontaining a solute of calcium and neurotransmitter glutamate receptors.Then, the third step is to seal the tumor by wrapping the entire treatedarea with a sealed waterproof plastic and/or rubber coating to confinethe reaction to only the tumor proper.

Such wrapped coating also tends to smother the tumor by denying accessto the wet and ion-rich extra-cellular space which is usually in closecontact with the cells of the tumor where it can absorb the raw materialfor operating the tumors cellular components.

By using saturated calcium C++ compounds wrapped around a cancer tumorisolates such malignancy for treatment without interfering with anyother body part nor interfere with the natural operations of the humanor animal body. The saturated cloth wraps may contain calcium C++molecules and other chemical compounds selected by the treatingphysicians. The amount of wetness and number of cloths applied isdeterminant as the proper treatment. The wraps can be removable and berepeated by any required number of courses as determined by the medicalstaff, including the length of time for each course.

The closure and smothering of the tumor with a waterproof plastic,rubber, or some other plastic material or even a clam-shell device thatisolates the tumor from other systems and body-part components orstructures from the treatment so that tumor is to itself, as relates tokilling the cancer. Treatment time may be in minutes, hours, or days asdetermined by the physician or oncologist who is applying the treatmentsystem.

The tumor target can be located anywhere within the body or on thesurface of the skin that the medical treatment team has access to. Asmany treatments can be repeated as deemed appropriate by the medicalteam. The important tactic is to isolate the tumor from every other partof the body, including sealing off of the blood vessels, whereveraccessible and practical.

In addition, electric neuro-signal treatments as revealed in otherpatents of the inventor and may also be conducted at the same time orafter the treatments as with the chemical methods described herein.

Another component of the treatment process is to utilize stimulation bya neurotransmitter such as glutamate in concert with a receptor areover-activated by NMDA and AMPA(a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor alongwith kainic acid), which binds to these receptors and can trigger anover-active glutamatergic storm, which is related to killing of thetumor cells.

The purpose for triggering the glutamatergic storm as part of thedestruction of the tumor is to launch an excitotoxicity event byallowing high levels of calcium ions to rush into the ion ports of thetumor cells at high levels of influx. Enzymes such as proteases,endonucleases, and phospholipases are part of the process to incite anexcitotoxic storm. Such enzymes can damage the cytoskeleton and plasmamembrane of the cancer cells along with the DNA in the nucleus.

When the high levels off, glutamate concentrates around the synapticcleft cannot balance the calcium ions at the necessary lower levelswhich disables the operation of the cancer cells. Thusly the cancer isunable to deal with the overload of calcium nor can the cells store theextra calcium in the endoplasmic reticulum, which it would normally do.But the load of calcium is just too great for the cells to correct. Thecancer cells being unable to rebalance their internal cell operationsleave them no choice but to kill themselves by the process of using itson-board nuclear program for cell-suicide to trigger apoptosis.

Still another damaging part of the described treatment of excessivecalcium in the tumor cellular cytosol is the opening of themitochondrial transition pore. With an open pore, the mitochondriaorganelle can swell and expand itself and malfunction to the point ofbeing unable to produce ATP which is the energy fuel for the cell. Theobvious result of these events is also programmed-cell-death byapoptosis or even karyorrhexis. Karyorrhexis is the fragmentation of thenucleus of the cells affected which is fatal to those cells experiencingsuch event.

All of the cancer cells are linked together so they can communicate;protect the tumor family from the immune system; share the availablenutrients and water; and be able to collectively locate in an area thathas a rich availability of ionic and molecular food.

The tumor collectively is equipped with programmed messages forreleasing cells to establish new metastatic colonies around the animalor human body or to even notify the cellular members of a givencancerous tumor that it is time to commit suicide. Besides releasingtumor cells to start new colonies, the tumor can send a message to anearby artery to have it bud and then grow an internal new arterynetwork internal to the tumor to serve as a blood source into thegrowing tumor. When the artery growth is complete, the internal lumen ofthe blood vessel is opened and blood allowed to flow. Because of thetreatment described, the tumor is unable to engage in the building andexpansion activities as described in this paragraph.

The results for damaging and killing the tumor by excitotoxicity willrange from 10 to 20 minutes up to several hours as a result of thedescribed treatments.

Osmotic-Shock

Osmotic-shock can be created as a treatment for relatively small groupsof cells as found with a small isolated tumor such as breast cancer or asmall cancer on the face or anywhere on the skin or scalp. However,osmotic-shock can tackle in-situ lung cancers or even pedunculated coloncancers and other circumscribed digestive tumors. Also, well-definedlung cancers and muscle tumors can be targeted with an osmotic-shock.

Creating an osmotic-shock event to destroy a definable tumor after“de-bulking” the tumor surgically could be undertaken by a medical teamin one or more procedures so that the size of the tumor is reduced insize, early in the treatment phase.

Osmotic-shock treatments to kill cancers are launched as a result of asudden change in the concentration of the ionic solutes around a body ofmalignant cells or a small tumor. To trigger osmotic-shock, there has tobe a large quantity of small ions in what can be called the supernatant.The supernatant is the aqueous liquid behind the ionic precipitatesolute. The solute is the quantity of ionic-bodies clinging around theoutside of the plasma membrane of a cell or group of cells. Oftenintentionally lowering the ionic particles which are concentrated arounda tumor can trigger the osmotic-shock as opposed to a high concentrationof ionic solutes being present.

Ca++ ions can damage cancer cells if they enter the cell through theplasma membrane pores in significant and excessive numbers. Excessiveentry of calcium into a cell might damage it or even cause it tounder-go death by necrosis, apoptosis, or karyorrhexis. Calcium also canbe a primary regulator or trigger to cause osmotic-shock.

Under high conditions of solutes outside the plasma membrane, water isdrawn out of the cells through cellular osmosis. On the other hand, lowconcentration of solutes and ions outside the cell causes water to bepulled into the aquatic or aqueous-ionic channels or ports in largeamounts, causing the cell to swell and to either burst or program-switchto enter an apoptosis and/or karyorrhexis phase. Either way, the canceris killed and cannot metastasize or infect other areas of the body.

Thus, if water wet cloth wraps surround a tumor and only calcium C2++along with other ionic particles or chemicals are available to bepositioned to work inside of the sealed reactive environment. The tumoris shielded from and protected from the extra-cellular environment. Theosmotic-shock events can be orchestrated by adjusting the reactiveingredients within the clam-shell very carefully by the medical team.The clam-shell tumor-jacket has gaskets or seals at every joint so thatit is waterproof. The extra-tumor environment cannot interfere with thereactive chamber that has been created by the medical and surgical teamto isolate the tumor from any exterior influence. Nothing inside thereactive-chamber should make contact to any living body part or tissueof the patient. Drapes can be used to protect nearby living tissue fromcontact with any cancerous malignant tumor or tissue. Appropriatemethods can be used to cut away the waterproof treatment jacket andretrieve it from the patients body without any leakage of the treatedtissue or waste treatment materials into the patient's body cavities. Inaddition, every element of the patient's body must be protectedincluding any orifice or fold, muscle, vital organ, limb, eyes, nose,blood vessels, or nerves of said body.

The clam-shell or sealing jacket may be constructed from plastic,rubber, or any other sealant material. Rubber, plastic or syntheticchemical seals, caulking materials, squeezable-tubes withpre-manufactured sealing materials can all be used to create awaterproof reactive tumor chamber to encase the tumor for treatment. Theclam-shell and gasket materials are all for one-time use only.Everything associated with encasing the tumor is disposable along withthe dead-tumor by the surgical team. The disposable materials are to betreated as infective hospital waste.

The chemical reaction or neuro-electric hybrid computer system which aresubject of other inventions by the inventor hereof may also be used.Barriers other than the fully closable clam-shell of any type may bedeemed to be appropriate by the surgical medical team. Entry through thebarrier wall should be done via grommets to retain the water/liquidintegrity management. Such passage through any barrier may be for addingor suctioning electrolytic ions, chemicals, or water. Also, entrythrough any barrier wall have to be provided for the acceptance ofoptical scopes, illumination devices, forceps, scalpels, probes, andelectrical leads to deliver neuro-coded signals.

The same technology can be used to kill benign or non-malignant tumorsby the same technology used for living cancer tumors.

The reaction time for causing osmotic-shock reactions to severely damageor kill the tumor is 10 to 20 minutes to hours depending on the size andlocation of the malignancy.

Anatomical Areas of the Human or Animal Body Suitable for TreatingMalignant Tumors

For example, treatment of lactation ductal carcinoma of the mammarygland which would likely be near the nipple could be approached bysurgical approach with incisions that would allow the use of theclam-shell encroachment to incase the tumor. The processes as describedin the patent would be followed and the method to cause apoptosis,excitotoxicity, or osmotic-shock reactions would be applied. After thetumor has been destroyed, the clam-shell and the tumor debris isremoved. Accessible blood vessels feeding the tumor would be permanentlyclosed off. Then, the breast incisions and access openings can be closedby appropriate sutures.

Performing a surgery of the thorax or abdomen to reach a cancer tumor isdone using the conventional surgical access procedures, followed by:using the clam-shell mechanism to provide closure of the cancer properand calcium, water management concerning homeostasis adjustment alongwith control of glutamate related receptors, including potentiallytaurine and thapsigargine to manage C++ efflux concentration.

Muscle and skin tumors require a straight forward access to provide theclam-shell system to apply the appropriate materials and chemicals tocause apoptosis, excitotoxicity, osmotic-shock, or karyorrhexisreactions.

The medical approach as can be appropriate for any areas of the animalor human body that cancer tumors are to be removed can use the methodsand materials described herein.

The use of the hybrid scientific computer described in other issuedpatents of the inventor is also available to use in addition to thepresent invention herein described. Said neuro-electric inventionrecords the intrinsic electrical signals found in cancer cells and thenreprograms such signals. Re-transmitting such reprogrammed treatmentsignals can be applied anywhere in or on the human or animal bodydepending on the size and location of the tumor to be treated.

Methods and systems are thus disclosed for the rapid destruction ofcancer tumor(s) which are made up of thousands to millions of livingmalignant cancer cells. This approach seeks to kill said tumor(s) bycausing apoptosis or excitotoxicity and/or osmotic-shock within a humanor animal for medical treatment.

Conventional targeted cancer therapies are drugs or other substancesthat block the growth and spread of cancer by interfering with specificmolecules involved in tumor growth and spreading or engaging inmetastatic colonization throughout the body. The disclosed embodiments,on the other hand, can implement a technology that kills the livingcancer cells directly and quickly leaving only dead cancer cells.

The disclosed embodiments can accomplish treatment during a time from,for example, 10 to 20 minutes up to multiple hours against a targetedcancer located in a human or animal. All malignant species are eligiblefor such treatment. Eukaryote classification consists of cellularorganisms whose individual cell contains a nucleus and other organellesenclosed within membranes. The dead tumors are removable from livepatients, leaving no live cancer cells.

In some embodiments, a reaction chamber can then be used to enclose thetumor in a water-tight sealed non-metallic clam-shell or any other styleof enclosure that the surgical team considers appropriate. Such areaction chamber can be sealed during the cancer killing process.

The reactive materials used within the clam-shell or other styleenclosures that destroys the malignant or benign tumor in a live patientcan include saturated calcium C++ compounds. In addition, de-ionizedand/or ionized waters, and glutamate transporters can be employed, whichcan accommodate excitotoxic reaction pathways. This includes the use ofAMPA and/or AMPAR which are quisqualate receptors for glutamatergicchemicals along with kainic acid, if needed, to trigger an overactiveglutamatergic storm. Destroying the malignant or non-malignant tumorcells may be accomplished within the clam-shell treatment chamber or byemploying any other enclosure to confine the cancer death process, whichwill also render the clean-up of the destroyed tumor more confined.

Arterial blood vessels that are feeding the tumor and venous vesselsthat are scavenging blood from the tumor should be clamped during themedical procedure to prevent contamination of other body structures bythe chemicals used in the clam-shell reaction chamber.

The treatment time for causing apoptosis, excitotoxicity, orosmotic-shock to cancer cells and/or malignant tumors is from 10 to 20minutes up to many hours, depending on the size and location of thetarget tumor.

The procedure described can also be utilized to treat benign tumors suchas uterine fibroid or muscle and limb tumors.

The cancer can also be attacked by recording its intrinsic cellularelectrical pattern and then reprogramming said signals so as to shutdown the operating signal system and causing the death of the cancer.

The methods and systems of shutting down the electrical signaling systemcan be transmitted throughout from one cell to its neighboring cells ina process of relaying the death codes, to electrically shut down theentire tumor.

It will be appreciated that variations of the above-disclosed and otherfeatures and functions, or alternatives thereof, may be desirablycombined into many other different systems or applications. It will alsobe appreciated that various presently unforeseen or unanticipatedalternatives, modifications, variations or improvements therein may besubsequently made by those skilled in the art, which are also intendedto be encompassed by the following claims.

What is claimed is:
 1. A system for the rapid destructions of tumors,said system comprising: an electronic device for recording signals of anintrinsic cellular electrical pattern associated with a tumor and thenreprogramming said signals to shut down an operation signal systemassociated with said tumor; wherein said electronic device is operablyconnected to an A-D (Analog-to-Digital) converter and a D-A(Digital-to-Analog) converter; a reaction chamber that encloses saidtumor in a water-tight sealed non-metallic compartment, wherein saidreaction chamber is sealed during a cancer killing process with respectto said tumor; and at least one reactive material employed within saidreaction chamber to destroy said tumor, wherein arterial blood vesselsfeeding said tumor are clamped during said medical procedure to preventcontamination of other body structures by said at least one reactivematerial used in said reaction chamber.
 2. The system of claim 1 whereinsaid at least one reactive material comprises saturated calcium C++compounds.
 3. The system of claim 1 wherein said at least one reactivematerial comprises at least one of: de-ionized and/or ionized water, andglutamate transporters that can accommodate excitotoxic reactionpathways.
 4. The system of claim 1 wherein said at least one reactivematerial comprises saturated calcium C++ compounds and de-ionized water.5. The system of claim 1 wherein said at least one reactive materialcomprises saturated calcium C++ compounds and ionized water.
 6. Thesystem of claim 1 wherein said at least one reactive material comprisessaturated calcium C++ compounds and glutamate transporters thataccommodate excitotoxic reaction pathways.
 7. The system of claim 1wherein said signals are initially recorded as analog signals andtransformed by said A-D converter into a digital format for saidreprogramming of said signals.
 8. The system of claim 1 wherein aftersaid reprogramming of signals in said digital format, said signals areconverted from said digital format into an analog format to shut downsaid operation signal system associated with said tumor.
 9. The systemof claim 1 wherein said reprogramming of said signals results in signalsthat initiate programmed-cell-death with respect to said tumor byapoptosis.
 10. The system of claim 1 wherein said reprogramming of saidsignals results in signals that initiate programmed-cell-death withrespect to said tumor by karyorrhexis.
 11. The system of claim 1 whereinsaid signals after reprogramming and conversion from said digital formalinto said analog format comprise treatment signals.
 12. The system ofclaim 1 wherein said electronic device comprises a hybrid scientificcomputer.
 13. The system of claim 12 wherein said hybrid scientificcomputer communicates electronically with a network of servers.
 14. Thesystem of claim 12 wherein said hybrid scientific computer communicateswirelessly with a network of servers.